Asimov, the artificial biology firm advancing the design and manufacture of therapeutics, at present introduced the enlargement of its LV Edge System with the launch of a completely secure cell line improvement service. There at the moment are two methods for patrons to entry Asimov’s cell line know-how to reduce value and manufacturing danger, relying on their wants:
- The LV Edge Packaging System, launched earlier this 12 months, which allows a single plasmid transfection that achieves E8 TU/mL.
- The brand new, fully-stable LV Edge Producer cell line improvement service, which generates clones that obtain E9 TU/mL with no transient transfection required.
The LV Edge Producer System utterly eliminates GMP plasmid value and drastically reduces course of complexity and variability by stably integrating all of the genes for lentiviral manufacturing into the host cell.
Present processes for lentiviral manufacturing are inherently scale-limited and variable because of the want for multi-plasmid transient transfection. Moreover, the reliance on GMP plasmids and transfection reagents considerably will increase prices and introduces provide chain and product variability dangers. The event of a completely secure cell line know-how allows scalable, reproducible and low-cost manufacturing of lentivirus, which can unlock purposes for bigger therapeutic indications.
LV Edge Producer Cell Traces obtain E9 TU/mL unconcentrated lentiviral titers for clinically related chimeric antigen receptor (CAR) transgenes. The service takes lower than 6 months from sequence switch to a secure, clonal cell line and is carried out in Asimov’s Boston cell line improvement facility.
We developed the LV Edge System to deal with the rising demand for scalable lentiviral manufacturing. As we speak’s launch expands the LV Edge portfolio, permitting therapeutic builders to decide on between an off-the-shelf single plasmid packaging system they will use in their very own lab, or a plasmid free cell line improvement service carried out by Asimov, reaching industry-leading titers in each circumstances. These advances had been made doable by integrating mammalian artificial biology, computational fashions, and our design software program (Kernel), furthering our purpose of democratizing state-of-the-art genetic design capabilities to our companions.
Alec Nielsen, Co-founder and CEO, Asimov
